Drug interactions
Amitriptyline + Olanzapine / samidorphan
Severity: Moderate
Amitriptyline and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amitriptyline and olanzapine cause sedation, orthostatic hypotension, and anticholinergic effects, so combining them can intensify these problems. Falls, confusion, constipation, and urinary retention are particular concerns in older adults.
What this interaction means in plain words
Amitriptyline and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, alpha-1 blockade, and antimuscarinic effects.
What to do
Monitor for sedation, orthostatic blood pressure drops, and anticholinergic symptoms, especially during titration. Reduce doses if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amitriptyline and Olanzapine / samidorphan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Amitriptyline and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amitriptyline and olanzapine cause sedation, orthostatic hypotension, and anticholinergic effects, so combining them can intensify these problems. Falls, confusion, constipation, and urinary retention are particular concerns in older adults.
How serious is the interaction between Amitriptyline and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic blood pressure drops, and anticholinergic symptoms, especially during titration. Reduce doses if symptoms develop.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
