Drug interactions
Amitriptyline + Olodaterol inhaled
Severity: Moderate
Amitriptyline and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists such as olodaterol, including tachycardia and QT prolongation. This raises concern for arrhythmias in susceptible patients.
What this interaction means in plain words
Amitriptyline and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and adrenergic cardiovascular stimulation.
What to do
Use olodaterol with caution in patients on tricyclics and consider ECG monitoring in those with cardiac disease or other QT risks. Correct low potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Amitriptyline and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists such as olodaterol, including tachycardia and QT prolongation. This raises concern for arrhythmias in susceptible patients.
How serious is the interaction between Amitriptyline and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use olodaterol with caution in patients on tricyclics and consider ECG monitoring in those with cardiac disease or other QT risks. Correct low potassium and magnesium.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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