Drug interactions
Amitriptyline + Phendimetrazine
Severity: Moderate
Amitriptyline and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic whose effects can be altered by tricyclics, and the combination may cause hypertension, tachycardia and arrhythmia. The interaction can also reduce the anorectic effect through blocked neuronal uptake.
What this interaction means in plain words
Amitriptyline and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics block uptake of indirect sympathomimetics into adrenergic neurons and inhibit norepinephrine reuptake, altering adrenergic responses.
What to do
Monitor blood pressure and heart rate and avoid the combination in patients with cardiovascular disease. Consider alternative weight management options.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Phendimetrazine?
MediHelp rates the interaction as moderate. Amitriptyline and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic whose effects can be altered by tricyclics, and the combination may cause hypertension, tachycardia and arrhythmia. The interaction can also reduce the anorectic effect through blocked neuronal uptake.
How serious is the interaction between Amitriptyline and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and avoid the combination in patients with cardiovascular disease. Consider alternative weight management options.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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