Drug interactions
Amitriptyline + Pirbuterol
Severity: Moderate
Amitriptyline and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline may amplify the cardiovascular effects of the beta-agonist pirbuterol, including tachycardia and arrhythmias. Product labeling for beta-agonists advises caution with tricyclics.
What this interaction means in plain words
Amitriptyline and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics inhibit noradrenaline reuptake and may potentiate the vascular and cardiac effects of beta-agonists.
What to do
Monitor heart rate, rhythm and blood pressure, and use the lowest effective pirbuterol dose. Consider an alternative bronchodilator if cardiovascular adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Pirbuterol?
MediHelp rates the interaction as moderate. Amitriptyline and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline may amplify the cardiovascular effects of the beta-agonist pirbuterol, including tachycardia and arrhythmias. Product labeling for beta-agonists advises caution with tricyclics.
How serious is the interaction between Amitriptyline and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, and use the lowest effective pirbuterol dose. Consider an alternative bronchodilator if cardiovascular adverse effects emerge.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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