Drug interactions
Amitriptyline + Quazepam
Severity: Moderate
Amitriptyline and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a benzodiazepine hypnotic, and combining it with amitriptyline increases sedation, psychomotor impairment, and the risk of falls. Next-day drowsiness is more likely, particularly in older patients.
What this interaction means in plain words
Amitriptyline and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and antihistaminic/sedative tricyclic effects.
What to do
Use the lowest effective doses and monitor for excess sedation and impaired coordination. Avoid alcohol and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Quazepam?
MediHelp rates the interaction as moderate. Amitriptyline and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a benzodiazepine hypnotic, and combining it with amitriptyline increases sedation, psychomotor impairment, and the risk of falls. Next-day drowsiness is more likely, particularly in older patients.
How serious is the interaction between Amitriptyline and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excess sedation and impaired coordination. Avoid alcohol and counsel on driving.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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