Drug interactions
Amitriptyline + Quercetin
Severity: Minor
Amitriptyline and Quercetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin inhibits P-glycoprotein and some CYP enzymes in vitro, but a clinically meaningful effect on amitriptyline exposure has not been shown. Any interaction is theoretical.
What this interaction means in plain words
Amitriptyline and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modulation of P-glycoprotein and CYP activity by quercetin; clinical significance unestablished.
What to do
No routine adjustment is needed. Monitor for changes in tricyclic effect if high-dose quercetin supplements are started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Quercetin?
MediHelp rates the interaction as minor. Amitriptyline and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quercetin inhibits P-glycoprotein and some CYP enzymes in vitro, but a clinically meaningful effect on amitriptyline exposure has not been shown. Any interaction is theoretical.
How serious is the interaction between Amitriptyline and Quercetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for changes in tricyclic effect if high-dose quercetin supplements are started or stopped.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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