Drug interactions
Amitriptyline + Thiothixene
Severity: Moderate
Amitriptyline and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and anticholinergic effects, and antipsychotics can also prolong QT. Amitriptyline may also raise antipsychotic levels through CYP2D6 competition.
What this interaction means in plain words
Amitriptyline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, anticholinergic and cardiac effects, with possible CYP2D6 competition.
What to do
Monitor for sedation, anticholinergic effects, orthostatic hypotension, and ECG changes. Use the lowest effective doses of each drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Thiothixene?
MediHelp rates the interaction as moderate. Amitriptyline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and anticholinergic effects, and antipsychotics can also prolong QT. Amitriptyline may also raise antipsychotic levels through CYP2D6 competition.
How serious is the interaction between Amitriptyline and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects, orthostatic hypotension, and ECG changes. Use the lowest effective doses of each drug.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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