Drug interactions
Amitriptyline + Thyroid desiccated
Severity: Moderate
Amitriptyline and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones can increase the sensitivity of adrenergic receptors to tricyclics, and this can increase the effects of amitriptyline. Cardiac arrhythmias and CNS stimulation may occur, and antidepressant response may also be augmented.
What this interaction means in plain words
Amitriptyline and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases catecholamine receptor sensitivity, enhancing the cardiovascular and CNS effects of the tricyclic.
What to do
Monitor heart rate, rhythm, and symptoms of agitation or tremor, especially when starting or increasing thyroid dose. Adjust either dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Thyroid desiccated?
MediHelp rates the interaction as moderate. Amitriptyline and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase the sensitivity of adrenergic receptors to tricyclics, and this can increase the effects of amitriptyline. Cardiac arrhythmias and CNS stimulation may occur, and antidepressant response may also be augmented.
How serious is the interaction between Amitriptyline and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm, and symptoms of agitation or tremor, especially when starting or increasing thyroid dose. Adjust either dose if toxicity appears.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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