Drug interactions
Amitriptyline + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Amitriptyline and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of the beta-agonist vilanterol, including tachycardia, hypertension and QT prolongation. Umeclidinium adds anticholinergic effects to amitriptyline's own anticholinergic burden.
What this interaction means in plain words
Amitriptyline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic and QT-prolonging effects, plus additive anticholinergic activity.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors. Watch for urinary retention, dry mouth and other anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Amitriptyline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of the beta-agonist vilanterol, including tachycardia, hypertension and QT prolongation. Umeclidinium adds anticholinergic effects to amitriptyline's own anticholinergic burden.
How serious is the interaction between Amitriptyline and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors. Watch for urinary retention, dry mouth and other anticholinergic effects.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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