Drug interactions
Amitriptyline + Valerian
Severity: Minor
Amitriptyline and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties and may add to the drowsiness caused by amitriptyline. Impaired alertness and psychomotor performance may result.
What this interaction means in plain words
Amitriptyline and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects, possibly via GABAergic activity of valerian.
What to do
Counsel patients about additive drowsiness and avoid driving if affected. Stop the herbal product if excess sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Valerian?
MediHelp rates the interaction as minor. Amitriptyline and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian has sedative properties and may add to the drowsiness caused by amitriptyline. Impaired alertness and psychomotor performance may result.
How serious is the interaction between Amitriptyline and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving if affected. Stop the herbal product if excess sedation occurs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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