Drug interactions
Amitriptyline + Yohimbine
Severity: Moderate
Amitriptyline and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine increases noradrenergic outflow, and tricyclic antidepressants may increase blood pressure responses to it. The combination may cause hypertension, tachycardia and anxiety, and yohimbine has been reported to blunt antidepressant effects.
What this interaction means in plain words
Amitriptyline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-2 antagonism by yohimbine increases norepinephrine release while the tricyclic blocks its reuptake, producing additive adrenergic effects.
What to do
Avoid unless clearly needed, and monitor blood pressure and heart rate. Reduce or stop yohimbine if hypertension or marked anxiety occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Yohimbine?
MediHelp rates the interaction as moderate. Amitriptyline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine increases noradrenergic outflow, and tricyclic antidepressants may increase blood pressure responses to it. The combination may cause hypertension, tachycardia and anxiety, and yohimbine has been reported to blunt antidepressant effects.
How serious is the interaction between Amitriptyline and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly needed, and monitor blood pressure and heart rate. Reduce or stop yohimbine if hypertension or marked anxiety occurs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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