Drug interactions
Amlodipine-benazepril + Amphotericin b deoxycholate
Severity: Moderate
Amlodipine-benazepril and Amphotericin b deoxycholate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conventional amphotericin B is the most nephrotoxic formulation and causes potassium and magnesium wasting, plus infusion-related hypotension. With an ACE inhibitor, acute kidney injury and hemodynamic instability are more likely, especially if the patient is volume depleted.
What this interaction means in plain words
Amlodipine-benazepril and Amphotericin b deoxycholate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal hemodynamic and tubular injury effects, with possible additive hypotension.
What to do
Monitor creatinine, potassium, magnesium and blood pressure frequently, and consider temporarily holding benazepril if renal function deteriorates or the patient becomes volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Amphotericin b deoxycholate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Amphotericin b deoxycholate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conventional amphotericin B is the most nephrotoxic formulation and causes potassium and magnesium wasting, plus infusion-related hypotension. With an ACE inhibitor, acute kidney injury and hemodynamic instability are more likely, especially if the patient is volume depleted.
How serious is the interaction between Amlodipine-benazepril and Amphotericin b deoxycholate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium, magnesium and blood pressure frequently, and consider temporarily holding benazepril if renal function deteriorates or the patient becomes volume depleted.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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