Drug interactions
Amlodipine-benazepril + Amyl nitrite
Severity: Moderate
Amlodipine-benazepril and Amyl nitrite: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amyl nitrite is a potent short-acting vasodilator, and the antihypertensives benazepril and amlodipine add to its blood pressure lowering effect. This can cause marked hypotension, dizziness, syncope and reflex tachycardia.
What this interaction means in plain words
Amlodipine-benazepril and Amyl nitrite can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through nitric oxide-mediated venous and arterial relaxation plus RAAS inhibition and calcium channel blockade.
What to do
Advise patients to sit or lie down when inhaling amyl nitrite and monitor blood pressure; avoid use in patients who are already hypotensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Amyl nitrite?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Amyl nitrite can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amyl nitrite is a potent short-acting vasodilator, and the antihypertensives benazepril and amlodipine add to its blood pressure lowering effect. This can cause marked hypotension, dizziness, syncope and reflex tachycardia.
How serious is the interaction between Amlodipine-benazepril and Amyl nitrite?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit or lie down when inhaling amyl nitrite and monitor blood pressure; avoid use in patients who are already hypotensive.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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