Drug interactions
Amlodipine-benazepril + Aprotinin
Severity: Moderate
Amlodipine-benazepril and Aprotinin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprotinin is used in cardiac surgery and inhibits kallikrein, which may blunt the effect of ACE inhibitors. It may reduce the antihypertensive effect of benazepril and has been associated with renal dysfunction.
What this interaction means in plain words
Amlodipine-benazepril and Aprotinin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Kallikrein inhibition by aprotinin reduces bradykinin-mediated vasodilation, which partly underlies the ACE inhibitor's effect.
What to do
Monitor blood pressure and renal function in the perioperative period, and follow local protocols for holding ACE inhibitors around surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Aprotinin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Aprotinin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprotinin is used in cardiac surgery and inhibits kallikrein, which may blunt the effect of ACE inhibitors. It may reduce the antihypertensive effect of benazepril and has been associated with renal dysfunction.
How serious is the interaction between Amlodipine-benazepril and Aprotinin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function in the perioperative period, and follow local protocols for holding ACE inhibitors around surgery.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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