Drug interactions
Amlodipine-benazepril + Aspirin / citric acid / sodium bicarbonate
Severity: Moderate
Amlodipine-benazepril and Aspirin / citric acid / sodium bicarbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic doses of aspirin can reduce the antihypertensive effect of ACE inhibitors by inhibiting vasodilating prostaglandins. Together they can also impair renal function, particularly in elderly or volume-depleted patients, and the sodium load from bicarbonate may add to this.
What this interaction means in plain words
Amlodipine-benazepril and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclooxygenase inhibition reduces renal prostaglandin synthesis, causing sodium retention and reduced glomerular perfusion that counteract ACE inhibitor effects.
What to do
Limit use of analgesic-dose aspirin products; monitor blood pressure and renal function, and ensure adequate hydration. Low-dose aspirin for cardiovascular prevention does not usually need adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Aspirin / citric acid / sodium bicarbonate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic doses of aspirin can reduce the antihypertensive effect of ACE inhibitors by inhibiting vasodilating prostaglandins. Together they can also impair renal function, particularly in elderly or volume-depleted patients, and the sodium load from bicarbonate may add to this.
How serious is the interaction between Amlodipine-benazepril and Aspirin / citric acid / sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use of analgesic-dose aspirin products; monitor blood pressure and renal function, and ensure adequate hydration. Low-dose aspirin for cardiovascular prevention does not usually need adjustment.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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