Drug interactions
Amlodipine-benazepril + Aspirin
Severity: Moderate
Amlodipine-benazepril and Aspirin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, aspirin can reduce the antihypertensive effect of benazepril and impair renal function, particularly in volume-depleted or elderly patients. Low-dose cardioprotective aspirin generally has little effect.
What this interaction means in plain words
Amlodipine-benazepril and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis opposes ACE inhibitor effects and reduces renal perfusion.
What to do
Monitor blood pressure and renal function when higher aspirin doses are used; low-dose aspirin for cardiovascular prevention can usually continue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Aspirin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, aspirin can reduce the antihypertensive effect of benazepril and impair renal function, particularly in volume-depleted or elderly patients. Low-dose cardioprotective aspirin generally has little effect.
How serious is the interaction between Amlodipine-benazepril and Aspirin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when higher aspirin doses are used; low-dose aspirin for cardiovascular prevention can usually continue.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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