Drug interactions
Amlodipine-benazepril + Atracurium
Severity: Moderate
Amlodipine-benazepril and Atracurium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may enhance and prolong neuromuscular blockade from nondepolarizing agents. The effect is mainly of concern in the perioperative setting.
What this interaction means in plain words
Amlodipine-benazepril and Atracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Atracurium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade reduces acetylcholine release at the neuromuscular junction, adding to nondepolarizing blockade.
What to do
Monitor neuromuscular function with a nerve stimulator and titrate atracurium doses accordingly during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Atracurium
Frequently asked questions
Can I take Amlodipine-benazepril with Atracurium?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Atracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers may enhance and prolong neuromuscular blockade from nondepolarizing agents. The effect is mainly of concern in the perioperative setting.
How serious is the interaction between Amlodipine-benazepril and Atracurium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and titrate atracurium doses accordingly during anesthesia.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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