Drug interactions
Amlodipine-benazepril + Bendroflumethiazide
Severity: Moderate
Amlodipine-benazepril and Bendroflumethiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and ACE inhibitors are commonly combined and have complementary blood pressure lowering effects. Initial doses can cause excessive hypotension, particularly in volume-depleted patients, and renal function may decline.
What this interaction means in plain words
Amlodipine-benazepril and Bendroflumethiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect from diuretic-induced volume depletion and RAAS inhibition.
What to do
Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug; consider lowering the diuretic dose before starting benazepril in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Bendroflumethiazide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Bendroflumethiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and ACE inhibitors are commonly combined and have complementary blood pressure lowering effects. Initial doses can cause excessive hypotension, particularly in volume-depleted patients, and renal function may decline.
How serious is the interaction between Amlodipine-benazepril and Bendroflumethiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug; consider lowering the diuretic dose before starting benazepril in volume-depleted patients.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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