Drug interactions
Amlodipine-benazepril + Cenobamate
Severity: Moderate
Amlodipine-benazepril and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control.
What this interaction means in plain words
Amlodipine-benazepril and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Cenobamate belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping cenobamate and increase the amlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Amlodipine-benazepril with Cenobamate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control.
How serious is the interaction between Amlodipine-benazepril and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping cenobamate and increase the amlodipine dose if needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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