Drug interactions
Amlodipine-benazepril + Cyclosporine
Severity: Major
Amlodipine-benazepril and Cyclosporine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can raise amlodipine exposure, and amlodipine may modestly raise cyclosporine concentrations. Benazepril combined with cyclosporine adds risk of hyperkalemia and reduced kidney function, particularly in transplant recipients.
What this interaction means in plain words
Amlodipine-benazepril and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 and P-glycoprotein-related pharmacokinetic effects, plus additive renal hemodynamic effects and potassium retention from ACE inhibition with cyclosporine.
What to do
Monitor cyclosporine trough levels, serum creatinine and potassium when starting or stopping the combination. Adjust the cyclosporine dose as needed and reduce amlodipine if hypotension or edema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Cyclosporine?
MediHelp rates the interaction as major. Amlodipine-benazepril and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can raise amlodipine exposure, and amlodipine may modestly raise cyclosporine concentrations. Benazepril combined with cyclosporine adds risk of hyperkalemia and reduced kidney function, particularly in transplant recipients.
How serious is the interaction between Amlodipine-benazepril and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels, serum creatinine and potassium when starting or stopping the combination. Adjust the cyclosporine dose as needed and reduce amlodipine if hypotension or edema occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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