Drug interactions
Amlodipine-benazepril + Dichlorphenamide
Severity: Minor
Amlodipine-benazepril and Dichlorphenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide promotes renal potassium loss and can cause hypokalemia and metabolic acidosis. Amlodipine does not meaningfully lower potassium, whereas benazepril tends to raise it, so the net effect is unpredictable and the legacy premise is doubtful.
What this interaction means in plain words
Amlodipine-benazepril and Dichlorphenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition increases urinary potassium loss, partly offset by ACE inhibitor potassium retention.
What to do
Monitor serum potassium and bicarbonate periodically during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amlodipine-benazepril with Dichlorphenamide?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Dichlorphenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dichlorphenamide promotes renal potassium loss and can cause hypokalemia and metabolic acidosis. Amlodipine does not meaningfully lower potassium, whereas benazepril tends to raise it, so the net effect is unpredictable and the legacy premise is doubtful.
How serious is the interaction between Amlodipine-benazepril and Dichlorphenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate periodically during combined use.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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