Drug interactions
Amlodipine-benazepril + Diltiazem
Severity: Moderate
Amlodipine-benazepril and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and raises amlodipine exposure, which can intensify hypotension and edema. Additive effects on vasodilation and cardiac conduction may also occur.
What this interaction means in plain words
Amlodipine-benazepril and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4-mediated metabolism of amlodipine, increasing its plasma concentrations, with additive calcium channel blockade.
What to do
Monitor blood pressure, heart rate and edema, and lower the amlodipine dose if hypotension or marked edema develops. Avoid the combination in patients prone to bradycardia or heart block.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Amlodipine-benazepril with Diltiazem?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and raises amlodipine exposure, which can intensify hypotension and edema. Additive effects on vasodilation and cardiac conduction may also occur.
How serious is the interaction between Amlodipine-benazepril and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and lower the amlodipine dose if hypotension or marked edema develops. Avoid the combination in patients prone to bradycardia or heart block.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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