Drug interactions
Amlodipine-benazepril + Erythromycin base
Severity: Moderate
Amlodipine-benazepril and Erythromycin base: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise amlodipine concentrations. This may cause hypotension, edema and, in older patients, a notable increase in effect.
What this interaction means in plain words
Amlodipine-benazepril and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by erythromycin.
What to do
Monitor blood pressure and edema during the antibiotic course, especially in older adults. Reduce the amlodipine dose if hypotension occurs or consider a non-CYP3A4-inhibiting antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Erythromycin base?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can raise amlodipine concentrations. This may cause hypotension, edema and, in older patients, a notable increase in effect.
How serious is the interaction between Amlodipine-benazepril and Erythromycin base?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during the antibiotic course, especially in older adults. Reduce the amlodipine dose if hypotension occurs or consider a non-CYP3A4-inhibiting antibiotic.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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