Drug interactions
Amlodipine-benazepril + Gold sodium thiomalate
Severity: Moderate
Amlodipine-benazepril and Gold sodium thiomalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold combined with ACE inhibitors has been associated with nitritoid reactions, including facial flushing, nausea, vomiting and hypotension. These reactions are rare but can be distressing and may lead to discontinuation of one of the agents.
What this interaction means in plain words
Amlodipine-benazepril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not firmly established; possibly related to vasodilatory effects potentiated by ACE inhibition.
What to do
Monitor for flushing, nausea and hypotension after gold injections, especially early in therapy. Consider an alternative antihypertensive if reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Gold sodium thiomalate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold combined with ACE inhibitors has been associated with nitritoid reactions, including facial flushing, nausea, vomiting and hypotension. These reactions are rare but can be distressing and may lead to discontinuation of one of the agents.
How serious is the interaction between Amlodipine-benazepril and Gold sodium thiomalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for flushing, nausea and hypotension after gold injections, especially early in therapy. Consider an alternative antihypertensive if reactions recur.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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