Drug interactions
Amlodipine-benazepril + Grapefruit
Severity: Minor
Amlodipine-benazepril and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may slightly raise amlodipine levels. Studies with amlodipine have shown only small changes in exposure, so a meaningful clinical effect is uncommon.
What this interaction means in plain words
Amlodipine-benazepril and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit constituents reduces first-pass metabolism of amlodipine.
What to do
No restriction is usually required for ordinary intake. Advise patients to report dizziness, flushing or ankle swelling if they consume large amounts of grapefruit.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Grapefruit?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and may slightly raise amlodipine levels. Studies with amlodipine have shown only small changes in exposure, so a meaningful clinical effect is uncommon.
How serious is the interaction between Amlodipine-benazepril and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No restriction is usually required for ordinary intake. Advise patients to report dizziness, flushing or ankle swelling if they consume large amounts of grapefruit.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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