Drug interactions
Amlodipine-benazepril + Heparin
Severity: Moderate
Amlodipine-benazepril and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress adrenal aldosterone production, and this effect adds to the potassium-retaining action of ACE inhibitors such as benazepril. Hyperkalemia may develop, particularly in patients with renal impairment, diabetes or other risk factors.
What this interaction means in plain words
Amlodipine-benazepril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis combined with ACE inhibitor reduction of angiotensin II-driven aldosterone release leads to additive potassium retention.
What to do
Check serum potassium and creatinine at baseline and periodically during prolonged heparin therapy. Treat hyperkalemia or review the need for the ACE inhibitor if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Amlodipine-benazepril with Heparin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress adrenal aldosterone production, and this effect adds to the potassium-retaining action of ACE inhibitors such as benazepril. Hyperkalemia may develop, particularly in patients with renal impairment, diabetes or other risk factors.
How serious is the interaction between Amlodipine-benazepril and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine at baseline and periodically during prolonged heparin therapy. Treat hyperkalemia or review the need for the ACE inhibitor if potassium rises.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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