Drug interactions
Amlodipine-benazepril + Indapamide
Severity: Moderate
Amlodipine-benazepril and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide and benazepril lower blood pressure additively, which may lead to symptomatic hypotension, particularly in patients who are volume depleted. Renal function can also worsen when a diuretic is combined with an ACE inhibitor.
What this interaction means in plain words
Amlodipine-benazepril and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Diuretic-related sodium and volume depletion increases dependence on angiotensin II, so ACE inhibition produces exaggerated hypotension and reduced glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and electrolytes after starting or changing either drug. Consider a lower initial ACE inhibitor dose in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-benazepril and Indapamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Indapamide
Frequently asked questions
Can I take Amlodipine-benazepril with Indapamide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide and benazepril lower blood pressure additively, which may lead to symptomatic hypotension, particularly in patients who are volume depleted. Renal function can also worsen when a diuretic is combined with an ACE inhibitor.
How serious is the interaction between Amlodipine-benazepril and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and electrolytes after starting or changing either drug. Consider a lower initial ACE inhibitor dose in volume-depleted patients.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
