Drug interactions
Amlodipine-benazepril + Iron dextran complex
Severity: Moderate
Amlodipine-benazepril and Iron dextran complex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral iron dextran can cause anaphylactoid reactions, and patients on ACE inhibitors may experience more severe reactions, including hypotension. Reports of this are limited, but the consequences can be serious.
What this interaction means in plain words
Amlodipine-benazepril and Iron dextran complex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not firmly established; ACE inhibition may impair compensatory responses to hypersensitivity and reduce bradykinin degradation.
What to do
Give a test dose and administer iron dextran only where resuscitation facilities are available, observing the patient afterward. Consider a non-dextran IV iron if an ACE inhibitor must continue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Iron dextran complex?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Iron dextran complex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral iron dextran can cause anaphylactoid reactions, and patients on ACE inhibitors may experience more severe reactions, including hypotension. Reports of this are limited, but the consequences can be serious.
How serious is the interaction between Amlodipine-benazepril and Iron dextran complex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give a test dose and administer iron dextran only where resuscitation facilities are available, observing the patient afterward. Consider a non-dextran IV iron if an ACE inhibitor must continue.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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