Drug interactions
Amlodipine-benazepril + Ketorolac intranasal
Severity: Major
Amlodipine-benazepril and Ketorolac intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use and, like other NSAIDs, can reduce the antihypertensive effect of benazepril and increase risk of acute kidney injury, especially with dehydration.
What this interaction means in plain words
Amlodipine-benazepril and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and opposes ACE inhibitor effects.
What to do
Limit ketorolac to the shortest course, ensure hydration, and monitor serum creatinine, potassium and blood pressure; avoid in renal impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Ketorolac intranasal?
MediHelp rates the interaction as major. Amlodipine-benazepril and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is absorbed systemically after intranasal use and, like other NSAIDs, can reduce the antihypertensive effect of benazepril and increase risk of acute kidney injury, especially with dehydration.
How serious is the interaction between Amlodipine-benazepril and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course, ensure hydration, and monitor serum creatinine, potassium and blood pressure; avoid in renal impairment.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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