Drug interactions
Amlodipine-benazepril + Meclofenamate
Severity: Moderate
Amlodipine-benazepril and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate may weaken the blood pressure lowering effect of benazepril and, in volume-depleted, elderly or renally impaired patients, can cause deterioration in kidney function.
What this interaction means in plain words
Amlodipine-benazepril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal vasodilatory prostaglandins opposes ACE inhibition.
What to do
Monitor blood pressure, creatinine and potassium, keep the patient hydrated, and use the lowest effective NSAID dose briefly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Meclofenamate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate may weaken the blood pressure lowering effect of benazepril and, in volume-depleted, elderly or renally impaired patients, can cause deterioration in kidney function.
How serious is the interaction between Amlodipine-benazepril and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, keep the patient hydrated, and use the lowest effective NSAID dose briefly.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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