Drug interactions
Amlodipine-benazepril + Mercaptopurine
Severity: Moderate
Amlodipine-benazepril and Mercaptopurine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors have been associated with additive myelosuppression when combined with marrow-suppressing drugs such as mercaptopurine. Leukopenia or neutropenia could occur.
What this interaction means in plain words
Amlodipine-benazepril and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Mercaptopurine belongs to Oncology.
Why it happens
Additive bone marrow suppression; ACE inhibitors may rarely cause neutropenia, mechanism not well established.
What to do
Monitor complete blood counts regularly, and reduce or interrupt mercaptopurine if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Mercaptopurine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors have been associated with additive myelosuppression when combined with marrow-suppressing drugs such as mercaptopurine. Leukopenia or neutropenia could occur.
How serious is the interaction between Amlodipine-benazepril and Mercaptopurine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, and reduce or interrupt mercaptopurine if neutropenia develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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