Drug interactions
Amlodipine-benazepril + Metformin
Severity: Minor
Amlodipine-benazepril and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly impair glucose control, while ACE inhibitors may improve insulin sensitivity, so glycemic effects may shift when therapy changes. Renal impairment from ACE inhibitors could rarely increase metformin accumulation and the risk of lactic acidosis.
What this interaction means in plain words
Amlodipine-benazepril and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Calcium channel blockers may reduce insulin secretion or sensitivity, ACE inhibitors may enhance insulin sensitivity, and ACE inhibitor-related renal decline can reduce metformin clearance.
What to do
Monitor blood glucose and renal function periodically. Reassess metformin dosing if eGFR falls significantly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Metformin
Frequently asked questions
Can I take Amlodipine-benazepril with Metformin?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly impair glucose control, while ACE inhibitors may improve insulin sensitivity, so glycemic effects may shift when therapy changes. Renal impairment from ACE inhibitors could rarely increase metformin accumulation and the risk of lactic acidosis.
How serious is the interaction between Amlodipine-benazepril and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function periodically. Reassess metformin dosing if eGFR falls significantly.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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