Drug interactions
Amlodipine-benazepril + Methyclothiazide
Severity: Moderate
Amlodipine-benazepril and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics add to the blood pressure lowering effect of ACE inhibitors and amlodipine. Volume depletion may cause first-dose hypotension and renal function decline.
What this interaction means in plain words
Amlodipine-benazepril and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect, with diuretic-induced volume depletion increasing the dependence of renal perfusion on the renin-angiotensin system.
What to do
Monitor blood pressure, renal function and electrolytes when starting or adjusting therapy. Correct volume depletion first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Methyclothiazide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics add to the blood pressure lowering effect of ACE inhibitors and amlodipine. Volume depletion may cause first-dose hypotension and renal function decline.
How serious is the interaction between Amlodipine-benazepril and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes when starting or adjusting therapy. Correct volume depletion first.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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