Drug interactions
Amlodipine-benazepril + Metipranolol
Severity: Minor
Amlodipine-benazepril and Metipranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol is an ophthalmic beta-blocker that can be absorbed systemically and may modestly add to the blood pressure and heart rate lowering of amlodipine. Rarely, bradycardia or hypotension can result, particularly in older patients or those with conduction disease.
What this interaction means in plain words
Amlodipine-benazepril and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive negative chronotropic and hypotensive effects from systemically absorbed beta-blockade combined with calcium channel blockade.
What to do
Check pulse and blood pressure after starting the eye drops, especially in patients with conduction abnormalities or heart failure. Teach nasolacrimal occlusion to reduce systemic absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Metipranolol?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metipranolol is an ophthalmic beta-blocker that can be absorbed systemically and may modestly add to the blood pressure and heart rate lowering of amlodipine. Rarely, bradycardia or hypotension can result, particularly in older patients or those with conduction disease.
How serious is the interaction between Amlodipine-benazepril and Metipranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check pulse and blood pressure after starting the eye drops, especially in patients with conduction abnormalities or heart failure. Teach nasolacrimal occlusion to reduce systemic absorption.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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