Drug interactions
Amlodipine-benazepril + Midazolam intranasal
Severity: Minor
Amlodipine-benazepril and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure. This may prolong or deepen sedation.
What this interaction means in plain words
Amlodipine-benazepril and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces midazolam clearance.
What to do
Monitor sedation level and respiratory status after intranasal midazolam, and allow for slower recovery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Midazolam intranasal?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure. This may prolong or deepen sedation.
How serious is the interaction between Amlodipine-benazepril and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after intranasal midazolam, and allow for slower recovery.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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