Drug interactions
Amlodipine-benazepril + Nifedipine
Severity: Major
Amlodipine-benazepril and Nifedipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine and amlodipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds to the risk of hypotension, peripheral edema, flushing and reflex tachycardia with no real benefit.
What this interaction means in plain words
Amlodipine-benazepril and Nifedipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive calcium channel blockade and vasodilation.
What to do
Avoid using two dihydropyridine calcium channel blockers together and keep only one. If the combination has been used, monitor blood pressure and edema.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Amlodipine-benazepril with Nifedipine?
MediHelp rates the interaction as major. Amlodipine-benazepril and Nifedipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nifedipine and amlodipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds to the risk of hypotension, peripheral edema, flushing and reflex tachycardia with no real benefit.
How serious is the interaction between Amlodipine-benazepril and Nifedipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridine calcium channel blockers together and keep only one. If the combination has been used, monitor blood pressure and edema.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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