Drug interactions
Amlodipine-benazepril + Nirmatrelvir / ritonavir
Severity: Moderate
Amlodipine-benazepril and Nirmatrelvir / ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and substantially raises amlodipine concentrations. This can produce hypotension, edema and dizziness that continue for several days after the antiviral course finishes.
What this interaction means in plain words
Amlodipine-benazepril and Nirmatrelvir / ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir inhibition of CYP3A4 reduces first-pass and systemic metabolism of amlodipine.
What to do
Consider lowering the amlodipine dose during treatment and for about three days after the last dose. Monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Nirmatrelvir / ritonavir?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Nirmatrelvir / ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP3A4 and substantially raises amlodipine concentrations. This can produce hypotension, edema and dizziness that continue for several days after the antiviral course finishes.
How serious is the interaction between Amlodipine-benazepril and Nirmatrelvir / ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the amlodipine dose during treatment and for about three days after the last dose. Monitor blood pressure and edema.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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