Drug interactions
Amlodipine-benazepril + Nirmatrelvir
Severity: Moderate
Amlodipine-benazepril and Nirmatrelvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir is given with ritonavir, a strong CYP3A4 inhibitor, which markedly increases amlodipine exposure. Hypotension, edema and dizziness may occur, and the effect persists for several days after the antiviral course ends.
What this interaction means in plain words
Amlodipine-benazepril and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Nirmatrelvir belongs to Anti Virals.
Why it happens
Ritonavir-boosted CYP3A4 inhibition decreases amlodipine clearance.
What to do
Consider reducing the amlodipine dose during the course and for a few days afterwards, or temporarily hold it if blood pressure allows. Monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Nirmatrelvir?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirmatrelvir is given with ritonavir, a strong CYP3A4 inhibitor, which markedly increases amlodipine exposure. Hypotension, edema and dizziness may occur, and the effect persists for several days after the antiviral course ends.
How serious is the interaction between Amlodipine-benazepril and Nirmatrelvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the amlodipine dose during the course and for a few days afterwards, or temporarily hold it if blood pressure allows. Monitor blood pressure and edema.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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