Drug interactions
Amlodipine-benazepril + Nitroglycerin po
Severity: Moderate
Amlodipine-benazepril and Nitroglycerin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral nitroglycerin dilates veins and arteries, and both amlodipine and benazepril lower blood pressure. Together they can cause additive hypotension, dizziness and syncope, particularly on standing.
What this interaction means in plain words
Amlodipine-benazepril and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation and reduced vascular resistance.
What to do
Monitor blood pressure and orthostatic symptoms, especially when starting or increasing doses. Counsel patients to rise slowly and adjust doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Nitroglycerin po?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral nitroglycerin dilates veins and arteries, and both amlodipine and benazepril lower blood pressure. Together they can cause additive hypotension, dizziness and syncope, particularly on standing.
How serious is the interaction between Amlodipine-benazepril and Nitroglycerin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially when starting or increasing doses. Counsel patients to rise slowly and adjust doses if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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