Drug interactions
Amlodipine-benazepril + Nitroprusside
Severity: Moderate
Amlodipine-benazepril and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroprusside is a powerful intravenous vasodilator, and amlodipine and benazepril add further blood pressure reduction. The combined effect can cause excessive hypotension, so nitroprusside titration may need to be more conservative.
What this interaction means in plain words
Amlodipine-benazepril and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through nitric oxide donation, calcium channel blockade and inhibition of angiotensin II formation.
What to do
Use continuous blood pressure monitoring and titrate nitroprusside carefully to the target. Expect lower infusion requirements in patients taking oral antihypertensives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Nitroprusside?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroprusside is a powerful intravenous vasodilator, and amlodipine and benazepril add further blood pressure reduction. The combined effect can cause excessive hypotension, so nitroprusside titration may need to be more conservative.
How serious is the interaction between Amlodipine-benazepril and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous blood pressure monitoring and titrate nitroprusside carefully to the target. Expect lower infusion requirements in patients taking oral antihypertensives.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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