Drug interactions
Amlodipine-benazepril + Penbutolol
Severity: Moderate
Amlodipine-benazepril and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with amlodipine and benazepril adds to blood pressure lowering. Dizziness, hypotension and occasionally bradycardia may occur, though the combination is often used intentionally.
What this interaction means in plain words
Amlodipine-benazepril and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects through beta-blockade, calcium channel blockade and ACE inhibition.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Penbutolol?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a beta-blocker with amlodipine and benazepril adds to blood pressure lowering. Dizziness, hypotension and occasionally bradycardia may occur, though the combination is often used intentionally.
How serious is the interaction between Amlodipine-benazepril and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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