Drug interactions
Amlodipine-benazepril + Pentobarbital
Severity: Moderate
Amlodipine-benazepril and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may lower amlodipine exposure, reducing blood pressure control. Barbiturates can also add to hypotension, particularly orthostatic effects, when combined with antihypertensives.
What this interaction means in plain words
Amlodipine-benazepril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 enzyme induction increases amlodipine metabolism, plus additive hypotensive and CNS depressant effects.
What to do
Monitor blood pressure and adjust the amlodipine dose if control is lost, particularly with repeated barbiturate use. Check for orthostatic hypotension after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Pentobarbital?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and may lower amlodipine exposure, reducing blood pressure control. Barbiturates can also add to hypotension, particularly orthostatic effects, when combined with antihypertensives.
How serious is the interaction between Amlodipine-benazepril and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the amlodipine dose if control is lost, particularly with repeated barbiturate use. Check for orthostatic hypotension after dosing.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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