Drug interactions
Amlodipine-benazepril + Phendimetrazine
Severity: Moderate
Amlodipine-benazepril and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate. This may oppose the antihypertensive effect of benazepril and amlodipine.
What this interaction means in plain words
Amlodipine-benazepril and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic pressor effects antagonize the blood pressure lowering of the antihypertensives.
What to do
Monitor blood pressure regularly while the patient is taking phendimetrazine. Adjust antihypertensive therapy or stop the anorectic if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Phendimetrazine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate. This may oppose the antihypertensive effect of benazepril and amlodipine.
How serious is the interaction between Amlodipine-benazepril and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly while the patient is taking phendimetrazine. Adjust antihypertensive therapy or stop the anorectic if blood pressure rises.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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