Drug interactions
Amlodipine-benazepril + Potassium acid
Severity: Major
Amlodipine-benazepril and Potassium acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce aldosterone and potassium excretion, so added potassium phosphate can cause hyperkalemia. The risk is greater in renal impairment, diabetes, or when other potassium-raising drugs are used.
What this interaction means in plain words
Amlodipine-benazepril and Potassium acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
ACE inhibitor-induced aldosterone suppression reduces renal potassium excretion, adding to the potassium load.
What to do
Check serum potassium and renal function at baseline and periodically, particularly in at-risk patients. Reduce or stop potassium supplementation if potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Potassium acid?
MediHelp rates the interaction as major. Amlodipine-benazepril and Potassium acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors reduce aldosterone and potassium excretion, so added potassium phosphate can cause hyperkalemia. The risk is greater in renal impairment, diabetes, or when other potassium-raising drugs are used.
How serious is the interaction between Amlodipine-benazepril and Potassium acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and periodically, particularly in at-risk patients. Reduce or stop potassium supplementation if potassium rises.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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