Drug interactions
Amlodipine-benazepril + Prazosin
Severity: Moderate
Amlodipine-benazepril and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prazosin is an alpha-1 blocker that adds to the blood pressure lowering of amlodipine and benazepril. First-dose or orthostatic hypotension and syncope may be exaggerated.
What this interaction means in plain words
Amlodipine-benazepril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive vasodilation through alpha-1 blockade, calcium channel blockade and ACE inhibition.
What to do
Start prazosin at a low dose at bedtime, monitor orthostatic blood pressure, and adjust doses gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Amlodipine-benazepril with Prazosin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prazosin is an alpha-1 blocker that adds to the blood pressure lowering of amlodipine and benazepril. First-dose or orthostatic hypotension and syncope may be exaggerated.
How serious is the interaction between Amlodipine-benazepril and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose at bedtime, monitor orthostatic blood pressure, and adjust doses gradually.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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