Drug interactions
Amlodipine-benazepril + Propranolol
Severity: Moderate
Amlodipine-benazepril and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol combined with amlodipine and benazepril produces additive blood pressure reduction. Hypotension, dizziness and bradycardia may occur, particularly when therapy is started or doses are raised.
What this interaction means in plain words
Amlodipine-benazepril and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects via vasodilation, RAAS inhibition and beta-blockade.
What to do
Monitor blood pressure and heart rate during initiation and dose changes, and lower doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Amlodipine-benazepril with Propranolol?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol combined with amlodipine and benazepril produces additive blood pressure reduction. Hypotension, dizziness and bradycardia may occur, particularly when therapy is started or doses are raised.
How serious is the interaction between Amlodipine-benazepril and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and dose changes, and lower doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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