Drug interactions
Amlodipine-benazepril + Rifampin
Severity: Moderate
Amlodipine-benazepril and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong inducer of CYP3A4 and can substantially reduce amlodipine concentrations. Loss of blood pressure or angina control may occur.
What this interaction means in plain words
Amlodipine-benazepril and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and intestinal efflux increases amlodipine clearance.
What to do
Monitor blood pressure during and after rifampin therapy and increase the amlodipine dose if needed. Reduce the dose again after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Rifampin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong inducer of CYP3A4 and can substantially reduce amlodipine concentrations. Loss of blood pressure or angina control may occur.
How serious is the interaction between Amlodipine-benazepril and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after rifampin therapy and increase the amlodipine dose if needed. Reduce the dose again after the inducer is stopped.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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