Drug interactions
Amlodipine-benazepril + Sildenafil
Severity: Moderate
Amlodipine-benazepril and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil produces vasodilation and can lower blood pressure, which adds to the effect of the antihypertensive combination. Symptomatic hypotension, dizziness or syncope may occur, particularly after the first doses.
What this interaction means in plain words
Amlodipine-benazepril and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilation through PDE5 inhibition combined with ACE inhibition and calcium channel blockade.
What to do
Start sildenafil at a low dose and monitor blood pressure and symptoms of orthostasis. Advise patients to rise slowly and report dizziness or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Sildenafil?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sildenafil produces vasodilation and can lower blood pressure, which adds to the effect of the antihypertensive combination. Symptomatic hypotension, dizziness or syncope may occur, particularly after the first doses.
How serious is the interaction between Amlodipine-benazepril and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at a low dose and monitor blood pressure and symptoms of orthostasis. Advise patients to rise slowly and report dizziness or fainting.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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