Drug interactions
Amlodipine-benazepril + Sodium bicarbonate
Severity: Minor
Amlodipine-benazepril and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium bicarbonate adds a sodium load and may modestly blunt the blood pressure response to benazepril. Antacid use may also slightly reduce ACE inhibitor absorption, though evidence is limited.
What this interaction means in plain words
Amlodipine-benazepril and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Sodium and fluid retention may oppose antihypertensive effect, and antacids may modestly alter ACE inhibitor absorption.
What to do
Monitor blood pressure if sodium bicarbonate is used regularly. Separate dosing by about two hours when feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Sodium bicarbonate?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium bicarbonate adds a sodium load and may modestly blunt the blood pressure response to benazepril. Antacid use may also slightly reduce ACE inhibitor absorption, though evidence is limited.
How serious is the interaction between Amlodipine-benazepril and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if sodium bicarbonate is used regularly. Separate dosing by about two hours when feasible.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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