Drug interactions
Amlodipine-benazepril + Sodium phosphates
Severity: Major
Amlodipine-benazepril and Sodium phosphates: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium phosphate bowel preparations can cause acute phosphate nephropathy, and ACE inhibitors increase that risk by reducing renal perfusion and compensatory responses, particularly with dehydration.
What this interaction means in plain words
Amlodipine-benazepril and Sodium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
ACE inhibition lowers glomerular filtration pressure, adding to phosphate-induced renal tubular injury and volume depletion.
What to do
Prefer a non-phosphate bowel preparation, or hold benazepril around the procedure and hydrate well. Check renal function if phosphate products are unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Sodium phosphates?
MediHelp rates the interaction as major. Amlodipine-benazepril and Sodium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sodium phosphate bowel preparations can cause acute phosphate nephropathy, and ACE inhibitors increase that risk by reducing renal perfusion and compensatory responses, particularly with dehydration.
How serious is the interaction between Amlodipine-benazepril and Sodium phosphates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-phosphate bowel preparation, or hold benazepril around the procedure and hydrate well. Check renal function if phosphate products are unavoidable.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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